Get Mystery Box with random crypto!

The hallmark of immune (also known as idiopathic) thrombocytop | Paediatrics videos & books

The hallmark of immune (also known as idiopathic) thrombocytopenia purpura (ITP) is the otherwise healthy appearing child with isolated thrombocytopenia. ITP is the most common cause of isolated thrombocytopenia in childhood. It occurs with equal frequency in both boys and girls. The presence of thrombocytopenia in a patient with otherwise normal cell lines, and a normal physical examination is enough to make the diagnosis, so further evaluation, such as a bone marrow biopsy, is unnecessary. Which children to treat and which treatment to use are areas of controversy in the management of ITP. Most acute ITP will resolve spontaneously, so many will recommend observation for children who appear well, are asymptomatic, and have platelet counts above 30,000. Platelet transfusions should be reserved only in the instance of ongoing or imminent bleeding. When a decision is made to treat, usually when the platelet count falls below 20,000, there are several options available. Treatment involves using IVIG, steroids, anti-D immunoglobulins, or combinations thereof. Combinations of medications may work synergistically. Prednisone is often used initially, as it can be given orally and is inexpensive. Typically, it will be tapered over 2 weeks to 3 months. By using combination therapy when needed, splenectomy can be avoided in the vast majority of cases. When it is necessary, it should be delayed, if at all possible, for at least a year after diagnosis.