2022-09-09 07:30:00
79) Explanation
Early manifestations of congenital infection vary and involve multiple organ systems.
• About 60% of infants born with congenital syphilis are asymptomatic at birth.
• Symptoms develop within the first 2 months of life. In symptomatic infants, the most common physical finding, seen in 100% of cases, is hepatomegaly.
• The other common findings are skeletal abnormalities, rash, and generalized lymphadenopathy.
• Radiographic abnormalities, periostitis or osteitis, involve multiple bones. Sometimes, the lesion is painful and an infant will favor an extremity (pseudopalsy).
• The rash is maculopapular and may involve palms and soles. In contrast to acquired syphilis, a vesicular rash and bullae may develop. These lesions are also highly contagious.
• Mucosal involvement may present as rhinitis (“snuffles”). Nasal secretions are highly contagious.
• Hematological abnormalities include anemia and thrombocytopenia. Late-onset congenital syphilis (diagnosed >2 y) Manifestations include neurosyphilis and involvement of the teeth, bones, eyes, and the eighth cranial nerve, as follows:
1. Bone involvement - Saber shins, saddle nose
2. Teeth involvement - Notched, peg-shaped incisors (Hutchinson teeth)
3. Pigmentary involvement - Linear scars (rhagades) at the corners of the mouth
4. Interstitial keratitis - Presents in the first or second decade of life
5. Sensory-neural hearing loss (eighth cranial nerve deafness)
6. Classic Hutchinson triad - (1) defective incisors, (2) interstitial keratitis, (3) eighth cranial nerve deafness
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