Uworld | Step 1

2022-09-01 08:18:02 Open / Comment

2022-09-01 08:17:01 Open / Comment

2022-08-31 21:18:01 Educational objective: The treatment of myasthenia gravis involves the use of a cholinesterase inhibitor, immunosuppressants, and possible thymectomy. Cholinesterase inhibitors may cause adverse effects related to muscarinic overstimulation, which can be ameliorated by the use of an antimuscarinic agent such as glycopyrrolate, hyoscyamine, or propantheline. Open / Comment

2022-08-31 08:18:01 Open / Comment

2022-08-31 08:17:01 The patient is started on appropriate treatment and reports significant symptom improvement. However, she now has abdominal cramping, nausea, sweating, and diarrhea. Open / Comment

2022-08-30 21:17:01 Educational objective: Myasthenia gravis is an autoimmune disease that causes a decrease in the number of functional acetylcholine receptors within the neuromuscular junction. This reduces the number of postsynaptic cation channels that can open in response to acetylcholine, which reduces the amplitude of motor end plate potential and prevents muscle fiber depolarization. Open / Comment

2022-08-30 08:17:01 Open / Comment

2022-08-30 08:16:02 A 62-year-old woman has double vision, especially when reading at bedtime. The problem first started several months ago and was intermittent but has worsened over the last 2 weeks and now bothers her constantly. The patient has also developed difficulty chewing and swallowing foods. She usually feels better in the mornings. She has no extremity weakness or sensory symptoms. The patient has no other medical problems and takes no medications. She does not use tobacco, alcohol, or illicit drugs. Vital signs are normal. BMI is 27 kg/m2• Examination shows bilateral ptosis; there is weakness of adduction of the right eye and abduction of the left eye. Muscle strength is 4/5 in proximal muscles in the upper and lower extremities. Deep tendon reflexes are 2+ throughout. Open / Comment

2022-08-29 22:34:56 https://t.me/studentdoctor Open / Comment

2022-08-29 21:16:01 Educational objective: Tetrahydrobiopterin (BH.) is a cofactor used by hydroxylase enzymes in the synthesis of tyrosine, dopamine, and serotonin. Phenylketonuria can result from BH. deficiency due to dihydropteridine reductase deficiency.
Intellectual disability is the hallmark of this condition and results in neurotransmitter
(eg, serotonin) deficiency and hyperphenylalanemia. Treatment involves a low phenylalanine diet and BH. supplementation. Open / Comment