Hypertonic saline is an osmotic agent uses to reduce the effects of secondary brain injury in patients with traumatic brain injury (TBI). This solution is given during the acute phase of the management of head injury because it is safe, inexpensive and has manageable side effects. It can be given during resuscitation, via continuous infusion, or as a bolus dose. 3% saline contain 513 mmol/l of Na+ and Cl each, osmol of 1026 mOsm/l; pH 5.0...... When compared with mannitol; Hypertonic saline is as effective for the treatment of raised ICP intraumatic brain injury as mannitol. It has less “rebound” intracranial pressure (ICP) With hypertonic saline there is o obligatory osmotic diuresis (plasma volume preserved/expanded) Mannitol may be nephrotoxic Hypertonic saline (3% NaCl) is reno-protective. In monitoring osmolality; For 3% NaCl one can use plasma sodium levels whereas for mannitol need to infer osmolar gap monitoring. #medicine #healthcare #manitol #surgery #medschool https://medcrine.com/hypertonic_saline 51 views19:30
