Platinum analogs (cisplatin, carboplatin) covalently bind to t | Medcrine

Platinum analogs (cisplatin, carboplatin) covalently bind to the DNA and work nonspecifically regarding the cell cycle. These drugs are used in the treatment of a number of tumors such as non-small cell lung cancer, small cell lung cancer, carcinoma of the head and neck, esophageal cancer, bladder cancer, ovarian cancer, germ cell carcinoma, non-Hodgkin's lymphoma).

They work by enhancing the tumor activity of etoposide and are widely used (cisplatin) as radiosensitizers.

Amifostine and mesna may ameliorate the nephrotoxicity.


There are three platinum analogs that are used clinically and these are;

Cisplatin,

Oxaliplatin and

Carboplatin


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https://medcrine.com/platinum-analogs-pharmacology