1- What is the pharmacokinatics ??? It,s action of the body on | First year Library

1- What is the pharmacokinatics ???
It,s action of the body on the drug this include absorption, distribution, metabolism and excretion.


2-What I mean when I said kinetics of the drug؟؟.

kinatics mean movement *kinasia*.. generally mean process need power to perform it . sush as absorbtion .

..
3- Definition of :
Absorption?

Its transfer of the drug from site of adminstration to BS.


4- Mechanism of absorption?

Passive and facilitated diffusion
,endocytosis
Endocytosis
And active transport.


5- Absorption depend on what ?

1- enviroment : where the drug is absorbed.
2- chemical properties of drug
3- rout of administration.


6- which kind of drug can passe through endocytosis؟

Vitamin B12.


7- How exocytosis happen??

*There are substant that storage in endogenous vacules and the cell release it by exocytosis .
Like: Neurotransmitters
*I think the administration of the neurotransmitter allow it to store in nerve endings
But when the body need it ,it released to the blood stream ( absorption).


8- Factors that influencing absorption?

*blood flow
*total surface area
*contact time at absorption surface
*and the PH.
* expression of p- glycoprotein.


9- what is the PKa?????

*PKa: is measure of the strength of interaction of a compound with a proton.

low PKa :more acidic drug
High PKa: more basic drug

It refer to PH of the medium of absorbtion.


10- what is the more efficient site of absorption?

*intestin
because it has:
long surface area ( microvilli).

rich blood flow
The last one : why I need to describe the kinetics of drug ?

to know the speed of onset of drug action
,intensity of the drug's effect , duration of drug action
and study movement of of the drug from entring the body antill be execrited.