2021-03-24 12:45:13
Ketamine is a commonly used intravenous anesthetic agent that is a noncompetetive inhibitor of N-methyl-D-aspartate (NMDA). It got its start as an anesthetic drug in the 1960s and approved for human use in 1970 when it was used on the battlefields of the Vietnam War.
Ketamine is a congenor or derivative of psychotomimetic agent known as phenycyclidine (PCP). Ketamine is related to phencyclidine but with less than 10% of the potency of pure phencylidine.
This anesthetic agent is known to be a cardiovascular stimulant and its use may lead to an increases intracranial pressure.
Ketamine is classified as category A in pregnancy and is primarily sold under the brand name Ketalar.
It can also be used to minimize discomfort associated with surgical manipulation or injection of local anesthetics.
It has two reisomers S-ketamine S (+) and R ketamine R(-). S-Ketamine exhibits dextrorotationandR-Ketamineexhibits levorotation. Of these S is more potent.
It is available in a clear liquid or off-white powder form that is used for intravenous injection.
Ketamine is known to cause dissociative anesthesia.
WHAT IS DISSOCIATIVE ANESTHESIA?
This is a kind of anesthesia produced by ketamine whereby a patient remains conscious but has marked catatonia, analgesia and amnesia (short-term memory loss).
Dissociative anesthesia is observed after induction with ketamine. The patient has eyes open with a cataleptic state which is a state with slow nystagmic activity.
Dissociative drugs cause distortion of color, sights,and sounds, self, and one's environment. Other examples of drugs with dissociative effects are include phencyclidine (PCP) and dextromethorphan (DXM).
https://medcrine.com/ketamine-pharmacology
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