What is a “last in, first out” theory of brain aging?
Studying age-related changes researches formed a hypothesis that the areas of the that experience the most dramatic changes with age are also among the last to mature in adolescence.
This theory was later confirmed and received the working name of “last in, first out”.
The phenomenon is explained by the fact that the first of the brain’s long-distance fibers to develop are the projection fibers connecting the cortex to lower parts of the brain and spinal cord. Fibers connecting diffuse areas within a single hemisphere — called association fibers — are the last to reach maturity and show the steepest functional declines with age.
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