Familial atypical multiple mole melanoma syndrome (FAMMM) This is an inherited skin condition in which there is multiple unusual nevi (see fig above).
It is inherited as
autosomal dominant disease with penetrance ranging from 50% to 92%.
The diagnosis is based on finding multiple unusual nevi and a family history of the same manifestation, the signficance of FAMMM syndrome is the development of
multiple malignant melanomas, and an increased risk for
pancreatic cancer. Treatment involve resection of malignant skin lesions, as well as
screening for pancreatic carcinoma.
