2021-12-23 10:17:45
Bones, stones, abdominal groans, and psychic moans These feature point to one thing,
excessive mobilisation of calcium from the bones to the blood. The term
"bones" refer to the bony pain due to heavy bone demineralisation and/or neoplastic infiltration of bones.
The resulting hypercalcemia causes severe smooth muscle contractions of intestine causing pain, hence
"abdominal groans", and surely, they will deposit in kidneys, and thats the
"stones".
At the surface on neurons, sodium channels are present, when these open sodium influx occur leading to an action potential, normally small amount of calcium is present on these channels, guarding these channels and controlling rate of Na influx, when calcium is so high, these calcium "guards" will increase around the Na channel, preventing Na influx and reducing neuronal excitation, causing depression and lethargy, and hence
"the psychic moans". These features classically occur in
primary hyperparathyroidism and in multiple myeloma "see fig above".
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