62. The powerful centrally acting antiemetic is? Ondansetron | FreeMedSite

62. The powerful centrally acting antiemetic is? Ondansetron

63. Metaclopromide is which receptor antagonist ? D2

64. Myeloaupression caused by methotrexate is rescued by whih drug? Leucovori

65. Anti Breast cancer drug having endometrial antagonist action is? Raloxifene

66. Myelosuppresion cause by 5 florouracil is rescued by? Thymidine

67. Hemorrhagic cystitis is side effect of ? Cyclophosphamide

68. Nephrotoxicity caused by cisplatin is prevented by? Amifostine

69. Name the drug which is Philadelphia chromosome tyrosine kinase inhibitor ?
Imatinib

70. Monoclonal antibody against CD20 is ? Rituximab

71. Probenecid inhibits reabsorption of Uric acid in which part of nephron? Proximal convulated tubule

72. Febuxostat inhibits? Xanthine oxidase

73. Antidote of acetaminophen ? N-acetylecystiene

74. Name anti-TNF antibody commonly used in crohn disease? Infliximab

75. Mechanism of aspirin? Irreversibly inhibit both COX 1 and COX 2

76. Warfarin effects which pathway ? Extrinsic pathway

77. Site of action of heparin? Blood

78. Heparin toxicity is treated by? Protamin sulphate

79. Clopidogrel toxicity cause which hematological deficiency? Neutropenia

80. Abciximab binds to which glycoproteins receptor? IIb/IIIa

81. Which drug is used or maintenance programe for opioid addicts? Methadone

82. Opioid used as cough suppressant ? Dextromethorphan

83. Drug of choice for absence siezures? Ethosuxemide

84. 1st line treatment of eclampsia? Mgso4

85. 1st line of treatment for acute epilepsy? Diazepam

86. Fetal hydantoin syndrome is teratogenicity caused by? Phenytoin

87. Neural tube defects caused by which drug? Valproic acid

88. Barbiturates facilitate GABA action by------of Cl channel ? Duration

89. Which inhaled anesthetic is hepatotoxic? Halothane

90. Most common drug used for endoscopy? Midazolam

91. IV anesthetic used for rapid and short procedures? Propofol

92. Main complication of succinylcholine ? Hypercalcemia and hyperkalemia

93. Malignant hyperthermia is treated hyperthermia ? Dantrolene

94. Benztropin improves------in parkinson disease ? Tremors and rigidity

95. Carbidopa is converted to ---- in CNS? Dopamine

96. Selegiline selectively inhibits ??? MAO-B

97. Half life of sumatriptan ?? <2 hours

98. Marked respiratory depression is caused by which depressants ? Barbiturates

99. Maurijuana can be detected in urine upto ------- months of last use? 1 month

100. Treatment of wernickie korsakoff syndrome is? IV Vitamin B1

101. Treatment of delerium tremens?? Benzodiazepines

102. Drug of choice for ADHD? Methylphenidate

103. Social phobias are treated with ? SSRI

104. Drug of choice for obsessive compulsive disorder is ? Clomipramine

105. All typical antipsychotics block which receptors? D2 receptors

106. Corneal deposits is side effect of which antipsychotics ?
Chlorpromazine
107. Treatment of neuroleptic malignant syndrome? Dantrolene

108. Which atypical antipsychotic May cause agranulocytosis ? Clozapine

109. Teratogenicity caused by lithium ? Ebstein anomaly

110. Generalized anxiety disorder is treated by? Buspirone

111. Drug of choice of bedwetting patient is? Imipramine

112. Main toxicity of tricyclics antidepressants? Convulsion , coma and cardiotoxicity.
113. How much time antidepressant need to have its effect? 4-8weeks

114. Antidepressant used for diabetic peripheral neuropathy is? Duloxetine

115. Drug used for altitude sickness? Acetazolamide

116. Name osmotic diuretic ? Mannitol

117. What is the effect of loop diuretic on calcium in the blood ?Hypocalcemia

118. Gout is side effect of which diuretic? Loop diuretic
119. Idiopathic hypercalciuria is treated with? Thiazide diuretics

120. While using ACE inhibitor what will be the effect on renin??? Renin level increases
121. Drug inhibits steroid synthesis ? Ketoconazole .

122. Contraindications of estrogens??? ER positive breast cancer and history of DVTs
123. a1-agonist used to treat BPH ? Tamsulosin

124. Mechanism of action of sildenafil? Inhibit cyclic GMP phosphodiesterse