Aging News: 1. Find out your age through your ear test: http | Longevity InTime Anti-Aging Digital Health Immortality Transhumanist Channel

Aging News:

1. Find out your age through your ear test:

https://itunes.apple.com/us/app/id1067630100?ls=1&mt=8

2. In 10 years we can make our blood younger?

https://news.cuanschutz.edu/news-stories/scientists-discover-ways-of-making-old-blood-new-again?hs_amp=true

https://www.fightaging.org/archives/2021/04/delivery-of-recombinant-serum-albumin-extends-life-span-in-old-mice/

3. Aging is a virus?

Our advisor shared with us:

“The most fashionable topic in aging right now, for obvious reasons, is the viral theory of aging. In general, there are even two of them.

First: viruses, or rather, infections, are to blame for everything.

According to this, aging is a way to quickly send an individual to the other world, so that it does not infect anyone. In fact, why then is there a cytokine storm? And sterile inflammation is, it turns out, such an examination for the body, which reveals interesting mutations that can withstand adversity.

There is even a version that eukaryotes arose due to viruses.

Peter Lidsky from the University of California hypothesizes that limiting life expectancy reduces the likelihood of epidemics and provides a corresponding mathematical model in his work.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395509/

In general, we should have a clear answer to the question of why life expectancy is under negative selection. From the Lidsky model, it follows that this is all for fighting infections.

But the naked mole rat, solved the problem of crowding and deadly infections by quickly killing the infected individual. This is the case with the herpes virus, which is easily transmitted by mice and humans, but is quickly lethal to the naked mole rat.

Viruses also fit well here as an adaptive mechanism for changing many human proteins.

"According to our conservative estimates, viruses cause about 30% of all adaptive amino acid changes in the part of the human proteome that is preserved in mammals. Our results suggest that viruses are one of the main drivers of evolutionary changes in mammalian and human proteomes, " says David Enard.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869911/


The negative role of inflammation in aging and activation of the Nf-KB pathway associated with the immune response to pathogens are also explained in the same way.

We see a strong immune response and survival in the reproductive period and the development of inflammatory conditions with aging.

In Drosophila, there was a study from American scientists when their immune activation to protect against pathogens and the active pro-inflammatory factor Nf-KB led to a shortened life.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2006.00251.x

The second group of theories is that "home viruses", mobile genetic elements, transposons, in fact, destroys the cell and make a decisive contribution to aging.

Recent work suggests that endogenous retroviruses can be activated during aging and cause senescence.

https://www.biorxiv.org/content/10.1101/2021.02.22.432260v1?fbclid=IwAR2l39bLihaVRrf2mWmXW42w89sCmhH7HCm9yUKBpwQ9yQbdRVTcLXGBvt8

In connection with the above, we have a healthy curiosity about companies that are engaged in manipulating transposons.

For example, there is a Transposage that has adapted transposons to genetic engineering.

https://biotech-365.com/transposagen-piggybac-transposon-system/

But I think now there will be a lot of companies that want to jam the traspozones.

PS. These two theories are not related in any way. Although anything can be.”

Updates:

Today we filed such petition in Russia - to rise average active age up to 100 years:

http://chng.it/gcWk92K4ZK

We plan to file the same in other 250 countries on 25 main languages.

Please sign it in 1 click for your own sake!

Thanks