The pyrimidine antagonists are a class of cancer chemotherapy | Medcrine
The pyrimidine antagonists are a class of cancer chemotherapy drugs that work by blocking the synthesis of pyrimidine containing nucleotides (C and T in DNA; C and U in RNA). These drugs are used to block the construction of these nucleotides. They have structures that resemble with the natural compound. Therefore by acting as 'decoys', they can prevent the production of the finished and functional nucleotides.
Pyrimidine antagonists may exert their effects at different steps in that pathway and may directly inhibit crucial enzymes in the cells. They may also be incorporated into a growing DNA chain and lead to termination of the process.
Examples of pyrimidine antagonists used in cancer therapy include:
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