Medcrine

2021-02-13 07:54:23 Finger clubbing is a deformity of the finger or toe nails due to a proliferation of connective tissue, on the dorsal surface of the fingers or toe nails.

Clubbing is usually associated with lung diseases such as interstitial lung disease, lung infection, lung cancer or cardiovascular disorder with featured hypoxic state.

Sometimes there may be an associated increased sponginess of the soft tissue at the base of the clubbed nail.

This clubbing is painless soft tissue swelling of the terminal phalanges with an increase in the convexity of the nail.

Normally, when the distal phalanges of the corresponding fingers of the opposite hands are opposed, a small diamond shaped window is formed between the nail beds.https://medcrine.com/finger-clubbing Open / Comment

2021-02-11 10:36:00 Open / Comment

2021-02-11 10:35:53 Overdiagnosis in psychiatry _ how modern psychiatry lost its way while creating a diagnosis for almost all of life's misfortunes ( PDFDrive ).pdf Open / Comment

2021-02-10 00:24:05 cardiac glycosides are organic compounds derived from a plant known as foxglove and used in the treatment of heart conditions.

These compounds are known to have positive inotropy meaning that they have the ability to increase the force of contraction of the heart muscle.

Examples of cardiac glycosides
There are a number of drugs under the class of cardiac glycosides but the common ones are:
Digoxin
Digitoxin
Ouabain

Digoxin is the most commonly used among these. It is an antiarrhythmic drug. Meaning that it is used in treating arrhythmias which are abnormal heartbeats. Arrhythmias are of various types but digoxin is mostly used in arrhythmias affecting the atria.

When looking at the mechanism of action we need to consider two modes of action by which digoxin works.

https://medcrine.com/cardiac-glycosides Open / Comment

2021-02-08 15:33:21 This is a nonexertional heat disorder occurring as an idiosyncratic reaction of skeletal muscles characterized by a hypermetabolic state that occurs in response to potent inhalation anesthetic agents and depolarizing muscle relaxants that used in anesthesia practice.

This exposure results in loss of normal calcium homeostasis within the skeletal muscles.

Inhalational agents that are associated with malignant hyperthemia include;

Halothane,
Sevoflurane, and
Desflurane,

The common depolarizing muscle relaxant associated with this problem is succinylcholine (suxamethonium),
https://medcrine.com/malignant-hyperthermia Open / Comment

2021-02-08 11:29:17 https://medcrine.com/oxford-handbook-of-clinical-medicine-pdf Open / Comment

2021-02-05 23:02:39 https://medcrine.com/clinical-practical-procedures-for-junior-doctors Open / Comment

2021-02-05 22:59:37 https://medcrine.com/kirks-basic-surgical-techniques Open / Comment

2021-02-02 23:34:03 https://medcrine.com/kirks-basic-surgical-techniques Open / Comment