Induced fit hypothesis This hypothesis was proposed | NEET_JEE_NCERT_TRICKS
Induced fit hypothesis
This hypothesis was proposed by Koshland (1960). According to this hypothesis the active site of the enzyme does not initially exist in a shape that is complementary to the substrate but is induced to assume the complementary shape as the substrate becomes bound to the enzyme. There are two ends
(a) Buttressing group is meant for supporting the substrate
(b) Catalytic group is meant for catalysing the reaction. When substrate comes in contact with the buttressing group, the active site changes to bring catalytic group opposite to the substrate.
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