The efficacy of single probiotic supplements is limited, compared with combined use of probiotics. Bifidobacterium plus prebiotic supplementation is the optimal intervention in reducing mortality; Lactobacillus plus prebiotic supplementation is the optimal intervention in reducing NEC morbidity. To achieve optimal effect on premature infant health, combined use of prebiotic and probiotic, especially Lactobacillus or Bifidobacterium, is recommended.
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https://doi.org/10.1542/peds.2020-0706
