#
Wernickle_Encephalopathy:
Neurological symptoms duo to vitamin B1(
TᕼIᗩᗰIᑎE ) deficiency :
1-
Encephalopathy : confusion
2-
Occulomotor dysfunction : nystagmus & abducent palsy
3 -
Ataxia: clumsiness and wide based gait.
#
Causes :
1- Malnutrition : eating disorder (anorexia nervosa), protien energy malnutrition
2 - Chronic alcoholism
3- Hypermesis gravidarum
#
Management :
No glucose containing fluid is given to a patient you suspect to have "
wernickle encephalopathy" ( administration of glucose in such conditions will further deplete body store of Vitamin B1 as its used robustly in glucose metabolism and therefore wernickle encephalopathy increases as in this patient).
Thiamine infusion then glucose.
#Reference :
Goldman-Cecil medicine 25th ed.
USMLE neurology.
http://static.us.elsevierhealth.com/goldman_cecilmedicine25e_9781455750177/9781455750177_0094
