#
Pharmacology:
Adverse drug reactions (ADR):
1- #Type_A (augmented) ADR:
dose dependent drug toxicity, it's when a drug reach a certain level that cause adverse effects #Example: acetaminophen and warfarin toxicity.
2- #Type_B (Bizarre) ADR:
Dose
independent unexpected drug reaction (aka
idiosyncratic) the smallest dose Can trigger adverse reaction #Example: Aspirin & Reye syndrome, hypertensivity reaction with Penicillin and #NMS with halopridol.
3- #Type_C (continuous) ADR: continuous adverse reaction for long time #Example : jaw osteonecrosis (picture) with bisphosphonate.
4- #Type_D (delayed) ADR also ADR:
Adverse effect appear late on similar to type B but this occur later on #Example Tardive dyskinesia with antipsycotics, teratogenic effect of anticonvulsants on fetus (fetal hydantoin syndrome) and analgesic nephropathy with Analgesics.
#Reference:
-Guidance on adverse drug reactions UK government pdf.
Image ONJ:
-https://ar.iiarjournals.org/content/33/9/3917
See:
https://t.me/spotdiagnosis/507
