Protip: Genetics and Fatloss Genetics greatly influences | Steroidify
Protip: Genetics and Fatloss
Genetics greatly influences fat loss, depending on your genes there will be a specific type of diet that is better.
FABP2 (rs1799883)
FABP2 refers to the intestinal fatty acid binding protein 2, which is a protein located in the cytosol of the intestinal epithelium and is associated with the metabolism of long chain fatty acids.
At rs1799883 a transition occurs at codon 54 resulting in a replacement of Alanine (Ala) with Threonine (Tr), the wild-type allele pattern for FABP2 is Ala / Ala while the mutant is Ala / Tr or Tr / Tr.
People with the mutant-type allele pattern would take advantage of a low-carb, high-fat diet while people with the wild-type allele pattern would take more advantage of a high-carb , low-fat diet.
PPARG2 (rs1801282)
This is the peroxisome proliferator activated receptor gamma-2 gene, which is an isoform of the PPARG gene. PPARG2 is found mainly in adipocytes and has a very important role in adipocyte differentiation.
At codon 12 of exon B in rs18001282 a mutation occurs consisting of a transition from alanine (Ala) to proline (Pro). The wild type allele pattern of PPARG2 is Pro / Pro, while the mutant type is Pro / Ala or Ala / Ala.
People with the mutant-type allele pattern would benefit more from a low-fat, high-carbohydrate diet.
ADRB3 (rs4994)
This is the beta-3 adrenergic receptor gene, which is found mainly in adipocytes and its function is related to lipid metabolism and thermogenesis.
At codon 64, a mutation can occur consisting of a transition from tryptophan (Trp) to arginine (Arg). The wild type allele pattern is Trp / Trp while the mutant type is Arg / Arg or Trp / Arg.
People with the mutant-type allele pattern would benefit more from a moderate carbohydrate and fat diet, those with a wild-type allele pattern would take advantage of a very high intake of PUFAs .
ADRB2 (rs1042713 and rs1041714)
This is the beta-2 adrenergic receptor gene which is distributed throughout the body, with a large presence in adipocytes and plays a very important role in lipid metabolism and thermogenesis.
The two most common genetic mutations in this gene occur at codons 16 and 27, respectively.
At codon 16 (rs1042713) arginine (Arg) replaces glycine (Gly); the homozygous allele pattern for Glycine is that of the wild type (Gly / Gly) while the other two are of the mutant type.
At codon 27 (rs1041714) glutamic acid (Glu) replaces glutamine (Gln); the homozygous allele pattern for Glutamine is of the wild type (Gln / Gln) while the other two are of the mutant type.
People with a wild-type allele pattern at codon 16 would need a greater caloric deficit to achieve the same weight loss , the same would happen for those with a mutant-type allele pattern at codon 27 .
#Genetics #Fatloss #Protip
