Educational objective: Huntington disease is an autosomal domi | Surgery collections Videos and quizez 2021

Educational objective: Huntington disease is an autosomal dominant neurodegenerative disease that leads to the accumulation of abnormal, toxic huntingtin protein in neural cells. Inhibitory GABAergic neurons in the caudate nuclei are most susceptible, and their loss is responsible for the characteristic manifestations of Huntington disease (eg, chorea, behavioral abnormalities).