​​ Prekallikrein and Hereditary Angioedema Hereditary angioe | UPDATES IN MEDICINE

​​ Prekallikrein and Hereditary Angioedema

Hereditary angioedema with C1 inhibitor deficiency, characterized by unpredictable and occasionally fatal swellings, is caused by uncontrolled activity of factor XIIa and plasma kallikrein, leading to locally increased vascular permeability. In a small, randomized, controlled trial, an antisense oligonucleotide drug targeting prekallikrein suppressed attacks by 90% over a 17-week period.

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