Correct Answer - A Ans. is 'a' i.e., Ketoconazole Pityriasis | Dermatology

Correct Answer - A
Ans. is 'a' i.e., Ketoconazole
Pityriasis versicolor (Tinea versicolor)
Tinea versicolor is a misnomer as it is not caused by dermatophyte;
Pityriasis versicolor is more appropriate term. It is caused by a
nondermatophyte fungus called Pityrosporum ovale (Malasezia
furfur). It usually affects young adults.
Clinical features
There are multiple small scaly hypopigmented macules (macules
may be hyperpigmented also). Scaling is furfuraceous or rice
powder like. Macules start around the hair follicles and then merge
with each other to form large areas. Affects trunk and shoulders
(mainly chest and back). There may be loosening of scales with
finger nails -4 Coupled onle or stroke of nail. Lesions are recurrent in
nature (may reappear after treatment).
Diagnosis of P.versicolor
Examination of scales in 10% KOH shows short hyphae and round
spores (Sphagetti and meat ball appearance). Wood's lamp shows
apple green fluorescence (blue-green fluorescence). Skin surface
biopsy —) A cyanoacrylate adhesive (crazy glue) is used to remove
the layer of stratum corneum on glass slide and then stained with
PAS reagent... Treatment of P.versicolor
1. Systemic agents : - Systemic azoles provide a convenient
therapeutic option. Drugs used are ketoconazole, Fluconazole or
intraconazole.
2. Topical antifungals :- Topical antifungals used are : -
i. Azoles —> Clotrimazole, econazole, Miconazole, Ketoconazole.
ii. Others —> Selenium Sulfide, Sodium thiosulphate, whield's
ointment (3% salicylic acid + 6% Benzoic acid).