Dermatology

2022-01-05 06:34:56 Many antimycotic agents negatively affect the natural immune response. Typically, these drugs impair polymorphonuclear leukocyte (PMN) production of superoxide anion, chemotaxis, or the killing of pathogens. Allylamines are a new class of antimycotic compounds with a new mechanism of antifungal action, i.e., inhibition of the fungal squalene epoxidase. The trial that we describe aimed to evaluate the effects of two allylamines, terbinafine and naftifine, on selected functions of PMNs, i.e., superoxide anion production, chemotaxis, and killing of Candida albicans blastospores. Terbinafine and naftifine on their own did not affect superoxide anion production when they were added to PMNs. When PMNs were preincubated with allylamines and were then stimulated by N-formyl-Met-Leu-Phe or phorbol 12-myristate 13-acetate, superoxide anion production was increased (priming effect). Since intracellular free calcium (Ca2+i) is involved in the control of superoxide anion production, we evaluated the effects of the allylamines on the Ca2+i concentration ([Ca2+]i). In the presence of terbinafine or naftifine, the [Ca2+]i increased in a dose-dependent manner; the source of Ca2+i was not extracellular since it was not affected by extracellular calcium chelation with ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid. In the presence of terbinafine or naftifine, chemotaxis of PMNs was not impaired. Terbinafine and naftifine slightly but significantly increased the killing of C. albicans blastospores (P < 0.05 at 10 and 100 microM). In conclusion, in contrast to imidazole-like drugs, the allylamine antimycotic compounds terbinafine and naftifine enhance selected functions of PMNs. Open / Comment

2022-01-03 13:59:32 Open / Comment

2022-01-01 19:39:06 28) A 25-year old wom an seeks consultation because of a solitary warty nodule on her neck. Histologic examination reveals tumor lobules composed of clear cells extending from the epidermis into the dermis with palisaded columnal cells at the periphery. The… Open / Comment

2022-01-01 19:34:43 28) A 25-year old wom an seeks consultation because of a solitary warty nodule on her neck. Histologic examination reveals tumor lobules composed of clear cells extending from the epidermis into the dermis with palisaded columnal cells at the periphery. The most appropriate course of action is to: Open / Comment

2021-12-29 15:10:03 Hexachlorophene is an antibacterial agent that was first introduced in 1944. Its use was discontinued in the 1970s when it was discovered to have neurotoxic side effects Open / Comment

2021-12-29 10:54:23 https://www.instagram.com/p/CYDqtu-BPox/?utm_medium=copy_link

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http://Www.instagram.com/spot_dx Open / Comment

2021-12-28 17:09:49 27) Mohs surgery fellow experiences burning and tingling of her fingertips 6 months after starting her fellowship. She most likely has been exposed to which one of the following chemicals? Open / Comment

2021-12-28 17:09:01 27) Mohs surgery fellow experiences burning and tingling of her fingertips 6 months after starting her fellowship. She most likely has been exposed to which one of the following chemicals? Open / Comment

2021-12-23 06:45:03 correct answer C

Explanation:

Clinical features of melanoma (ABCDES)
Assymetry : , the 2 sides are not identical • Border irregularities : uneven edges
• Color variegation Varaties pictures of brown, tan black md •
Diameter 20 mm .
Evolving Lesion changing in the shape, or color, new lesion

This patient's family history of skin cancer the melanocytic lesion seen on skin examination, and her 1-week history of focal neurologic deficit suggest that her seizure results from malignant melanoma metastatic to the central nervous system Melanoma commonly metastasizes to the brain, gastrointestinal tract, bone, liver, and lungs it is a malignancy of melanocytes, which are of neural crest origin

(Choice A) The endoderm gives rise to all structures derived from the inner lining of the primitive gut tube. These include the thyroid folicular cells; epithelial surfaces of the trachea, bronchi, and lungs liver and biliary treo pancreas, and gastrointestinal and bladder epithelium.

(Choice B) The mesoderm gives rise to the dermis as well as most bones muscles, blood vessels, and visceral tissue

(Choice D) The neuroectoderm gives rise to the central nervous system preganglionic autonomic neurons, retina, and posterior pituitary Open / Comment

2021-12-22 07:43:47 Open / Comment