Explanation • Antipyschotics targeting positive symptoms pro | NEET PG/NEXT (MCQs)

Explanation

• Antipyschotics targeting positive symptoms probably act by blocking the postsynaptic dopamine(D2) receptors in the mesolimbic system. Other receptors such as 5-HT, muscarinic receptors and GABA are also probably important. Atypical antipsychotics are also called as Serotonin Dopamine Antagonists (SDAs) due of their action on both dopamine and 5-HT
• Overactivity of DA receptor causes positive symptoms
• Their blockage of D2 antagonist relieves from positive symptoms
• Underactivity of NMDA receptor is responsible for negative symptoms.