2022-01-03 16:47:07
Microbiology 2 class 48:
Neutrophils PMNs lobed or segmented 60 -70% increased in inflammation diapedesis acute infections
Granulocyte neutrophils , basophiles , eosinophiles
Bilobed granulocyte basophiles, eosinophiles
Basophiles allergic reaction
Eosinophiles parasitic infections
Neutrophils inflammation & acute infections
Agranulocyte
monocytic monocytes macrophages , dentritic cells , natural killer
lymphoids b- cells , T-cells
Macrophages
Liver kupffer cells
lung alveolar macrophages
brain microglia
Bones osteoclast
Natural killer NK non phagocytic lymphoid cells large granular lymphocytes LGL
Apc antigen presenting cells
Lymphoid cell b cell & dentritic cells
Amyloid macrophages & dentritic cells
First line defense
Skin physical , chemical , biological barriers
Respiratory tract physical , biological barriers
Git biological, chemical
Genitourinary tract physical, chemical , biological
Conjunctiva physical , chwmical
Second line defense
Inflammation
Fever
Phagocytosis
Antimicrobial substances coagulation system , lactoferrin calprotectin psorian , lysozyme , interferon , complement system
Inflammation
1 vasodilation by chemicals
2 chemotaxis
3 phagocytosis margination , diapedesis
4 engulf microbes , dead damaged debris
5 tissue repair
Phagocytosis occured by neutrophils followed by macrophages followed by denteritic
Lysozyme found in all body fluids especially tears except CSF , urine
Opsonin antibodies & complement (C3b , C4b)
Alternative pathway is spontaneously activated
The only antibody dependent pathway is classical pathway
C4bC2a is called C3 convertase
C4bC2aC3b C5 convertase
In classical pathway
Lectin pathway form MBL / MASP-1/MASP-2 activate MASPs cleavage of C4 & C2 C3 convertase
C3(H2o)Bb + properdin c3 convertase enzyme
In Alternative pathway
Humeral system antibodies
B cells
Cellular system cells eliminate pathogens
T cells
Helper T cells CD4 binds to class 2 MHC molecules has a role in humoral & cellular responses
T-helper 1 (Th1) intracellular pathogens cellular immunity interferon gamma
T-helper 2 exogenous antigen humerol immunity interleukin
Cytotoxic T cell secrets perforin
CD 8 MHC class 1
Class 1 MHC nucleated cell CD8 + cytotoxic T cell exogenous antigens
Class 2 MHC antigen presenting cells CD4+ helper T cells endogenous antigens
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