NIIMA, Network of Immunity in Infection, Malignancy and Autoimmunity

2022-07-31 06:01:13 BNT162b2 mRNA COVID-19 Vaccine Does Not Impact the Honeymoon Phase in Type 1 Diabetes: A Case Report

New Paper by USERN Interest Group

Recently, there has been an increasing concern that COVID-19 vaccination may trigger autoimmune phenomena.

We describe the case of a 24-year-old young Italian man with T1D who received two doses of the BNT162b2 mRNA (Pfizer-BioNTech) COVID-19 vaccine during a prolonged honeymoon phase.

Source: https://doi.org/10.3390/vaccines10071096

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2022-07-29 22:32:36 ONLY 48 HOURS left until the congress early registration deadline

We respectfully inform you that after completing registration form, applicants should finalize their registration by paying the registration fee. The deadline for early registration is 31 July 2022 and will not be extended. Then late registration fee will be applied

Find the answers to your questions here:
https://t.me/usern_congress/1082

Early registration

Abstract submission

More information:
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usern.congress2022@gmail.com
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2022-07-29 06:00:32 Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

New Paper by USERN Interest Group

Currently, the majority of JAK–STAT-targeting drugs are still at preclinical stages.

Meanwhile, a variety of plant polyphenols, especially quercetin, exert their inhibitory effects on the JAK–STAT pathway through known and unknown mechanisms.

Quercetin has shown prominent inhibitory effects on the JAK–STAT pathway in terms of anti-inflammatory and antitumor activity, as well as control of neurodegenerative diseases.

This review discusses the pharmacological effects of quercetin on the JAK–STAT signaling pathway in solid tumors and neurodegenerative diseases.

Source: https://doi.org/10.1186/s11658-022-00355-3

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2022-07-28 03:30:56 With great sadness, we announce the loss of Professor Colin Blackmore, one of our advisory board members.

He was a professor of Neuroscience at City University of Hong Kong and Chief Executive of the UK Medical Research Council. He worked in the medical schools of Cambridge and Oxford for more than 40 years.

On behalf of the entire team, please accept our sympathies.

https://usern.tums.ac.ir/User/CV/Colin_Blakemore

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2022-07-27 06:16:14 Oral antiviral treatments for COVID-19: opportunities and challenges

New paper by USERN Interest Group, Junior Ambassadors' Collaboration

Presents the potential pharmaceutical antiviral targets, including various host-based targets and viral-based targets

Characterizes the first-generation anti-SARS-CoV-2 oral drugs (nirmatrelvir/ritonavir and molnupiravir)

Summarizes the clinical progress of other oral antivirals for use in COVID-19

Discusses ethical issues in such clinical trials

Presents challenges associated with the use of oral antivirals in clinical practice

Source: https://link.springer.com/article/10.1007/s43440-022-00388-7

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2022-07-25 14:46:09 Less than 7 days left to the congress early registration deadline

Program at a glance:
8th International Festival of Paintings for Pediatric Patients (IFPPP)
Virtual scientific programs and workshops
Scientific lectures and workshops by more than 70 top 1% scientists
Unique opportunity for juniors to present their scientific lectures
Announcement of USERN Prize Laureates

The deadline for early registration is 31 July 2022 and will not be extended. Then late registration fee will be applied

A unique opportunity to present your research among the elite scientists in the context of Junior Talks/Posters!

Early registration:
https://docs.google.com/forms/d/e/1FAIpQLSd6cIZ_ZbZpGsvA0IHP30kU24ATfdC2OY9MBoWezPn1SQBtUQ/viewform?usp=sf_link

More information:
userncongress.tums.ac.ir
usern.congress2022@gmail.com
@USERN_Congress2022

#USERN2022

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2022-07-24 04:54:14 The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors

New Paper by USERN Interest Group

The cross-feeding and metabolic coupling of CAFs and tumor cells are also affected by metformin. Therefore, the importance of metabolic reprogramming of stromal cells and also the pivotal effects of metformin on TME and oncometabolites signaling pathways have been reviewed in this study.

Source: https://doi.org/10.1186/s11658-022-00356-2

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2022-07-22 11:10:06 Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis

New Paper by USERN Interest Group

Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival, differentiation, development, and plasticity. Evidence suggests that fluctuations in peripheral levels (i.e., plasma or serum) of BDNF are associated with eating behaviors.

Nevertheless, the findings are inconsistent. The purpose of this study is to determine if serum or plasma levels of BDNF are altered in individuals with eating disorders (EDs) compared to controls.

Lower BDNF levels are associated with EDs.

Source: https://doi.org/10.1186/s40337-022-00630-w

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2022-07-21 10:31:08 Possible role of autophagy induced by COVID-19 in cancer progression, chemo-resistance, and tumor recurrence

New Paper by USERN Interest Group

Studies suggest that cancer patients are one of the most susceptible populations to experience severe COVID-19 and death.

Targeting autophagy-related signaling pathways and cellular and molecular processes could be a potentially promising therapeutic approach for cancer patients with COVID-19. 

Source: https://doi.org/10.1186/s13027-022-00450-2

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2022-07-20 02:36:42 Clinical safety and efficacy of bispecific antibody in the treatment of solid tumors: A protocol for a systematic review

New Paper by USERN Interest Group

The aim of this systematic review and meta-analysis will be to determine the safety and efficacy of BsAbs in the treatment of solid tumors.

The findings of the present study will provide information on safety and efficacy of BsAbs for physicians and researchers in the management of solid tumors.

Source: https://doi.org/10.1371/journal.pone.0271506

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