81) Explanation Since the neonate developed Jaundice on day 3 | Paediatrics videos & books

81) Explanation

Since the neonate developed Jaundice on day 3 of life it indicates physiological jaundice. It appears when total serum bilirubin exceeds 5 mg% and progresses in cephalocaudal direction.
Dermal pressure may reveal the anatomic progression of
1. Face = 5 mg/dL
2. Mid-abdomen = 15 mg/dL
3. Soles = 20 mg/dL
The yellow color usually results from the accumulation of unconjugated, nonpolar, lipid-soluble bilirubin pigment in the skin.
• This unconjugated bilirubin is an end product of hemeprotein catabolism from a series of enzymatic reactions by heme-oxygenase and biliverdin reductase and nonenzymatic reducing agents in the reticuloendothelial cells