CTV Delineation for High-Grade Gliomas: Is There Agreement Wit | Radiation Oncology | Articles preview

CTV Delineation for High-Grade Gliomas: Is There Agreement With Tumor Cell Invasion Models?
https://www.advancesradonc.org/article/S2452-1094(22)00094-X/fulltext?rss=yes

High-grade glioma (HGG) is a common form of malignant primary brain cancer with poor prognosis. The diffusive nature of HGGs implies that tumor cell invasion of normal tissue extends several centimeters away from the visible gross tumor volume (GTV). The standard methodology for clinical volume target (CTV) delineation is to apply a 2-3 cm margin around the GTV. However, tumor recurrence is extremely frequent. The purpose of this paper was to introduce a framework and computational model for the prediction of normal tissue HGG cell invasion and to investigate the agreement of the conventional CTV delineation with respect to the predicted tumor invasion.