Predictors of acute hematologic toxicity in women receiving ex | Radiation Oncology | Articles preview

Predictors of acute hematologic toxicity in women receiving extended-field chemoradiation for cervical cancer: Do known pelvic radiation bone marrow constraints apply?
https://www.advancesradonc.org/article/S2452-1094(22)00104-X/fulltext?rss=yes

Objectives Cervical cancer patients at high risk for para-aortic lymphatic involvement may receive extended-field chemoradiation (EF-CRT), with inclusion of the para-aortic region. Increased radiation to bone marrow (BM) may heighten hematologic toxicity (HT) and impact timely delivery of chemoradiation. Factors associated with HT in this setting have not been well-studied.Methods This is a retrospective analysis of women treated with EF-CRT from 2012-2018 with platinum-based chemotherapy. Factors including age, body mass index (BMI), race, Charlson Comorbidity Index (CCI), and nadirs for white blood cell count, absolute neutrophil count, hemoglobin, and platelet count were collected.