UPDATES IN MEDICINE

2021-11-05 03:57:17 ​​ Pfizer (BNT162b2) Vaccine at 6 Months of Follow-up

In a multinational, observer-blinded, randomized trial involving 44,165 participants 16 years of age or older and 2264 participants 12 to 15 years of age, the efficacy of the BNT162b2 vaccine was 91% against Covid-19 and 97% against severe disease through 6 months of follow-up. In South Africa, where the beta variant was widespread, vaccine efficacy was 100%. Late toxic effects from the vaccine were not observed.


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2021-10-31 08:09:27 ​​ Ticagrelor versus Clopidogrel in Stroke or TIA

In a trial in China, patients with a minor stroke or transient ischemic attack with CYP2C19 loss-of-function alleles as determined by point-of-care testing had modestly fewer second strokes with ticagrelor than with clopidogrel but also had more total bleeding events.


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2021-10-28 18:02:57 ​​ Another new monoclonal antibody, Sotrovimab for Early Covid-19

In this ongoing, randomized, phase 3 trial, sotrovimab (a SARS-CoV-2–targeted monoclonal antibody) or placebo was administered to outpatients within 5 days after the onset of Covid-19 symptoms. The incidence of hospitalization for any cause was lower among patients who received sotrovimab (1% vs. 7%).


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2021-10-26 04:36:40 ​​ SIR Guidelines on IVC Filters for Venous Thrombo Embolic Disease

Society of Interventional Radiology Clinical Practice Guideline for Inferior Vena Cava Filters in the Treatment of Patients with Venous Thromboembolic Disease


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2021-10-23 14:56:46 ​​ Covid-19 Vaccination in Early Pregnancy and Miscarriage

In this case–control study performed with the use of registry data in Norway, there was no evidence of an increased risk of first-trimester pregnancy loss associated with Covid-19 vaccination during early pregnancy.


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2021-10-21 15:30:00 ​​ Lanifibranor - A new effective drug for NASH

Lanifibranor is a pan–peroxisome proliferator–activated receptor agonist that modulates metabolic and inflammatory pathways. In this 24-week, phase 2b, placebo-controlled trial involving patients with NASH, 1200 mg of lanifibranor, significantly improved histologic features of NASH.
Weight gain, anemia, peripheral edema, diarrhea, and nausea occurred more frequently with lanifibranor than with placebo.


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2021-10-14 14:41:06 ​​ Empagliflozin - a breakthrough for heart failure with preserved EF

In a randomized trial, 5988 patients with heart failure with preserved ejection fraction were assigned to receive either empagliflozin or placebo in addition to usual therapy. At a median of 26 months, the empagliflozin group had a lower incidence of cardiovascular death or hospitalization for heart failure than the placebo group.


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2021-10-13 16:54:57 ​​ 2021 AASLD Guidelines on Ascites, SBP and Hepatorenal Syndrome

Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the Study of Liver Diseases


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2021-10-11 16:00:02 ​​ Broadly Neutralizing Antibodies against Coronaviruses

People who recovered from SARS-CoV-1 infection in 2002–2003 have neutralizing antibodies documented for up to 17 years. Vaccinating such people with the BNT162b2 SARS-CoV-2 vaccine elicited high titers of antibodies capable of neutralizing not only all SARS-CoV-2 variants of concern but also coronavirus types found in bats and pangolins. Immunity against all beta-coronaviruses may be achievable.


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2021-10-10 16:50:00 ​​​​ Immediate vs. Delayed Drainage for Infected Necrotizing Pancreatitis

A multicenter, randomized trial of patients with infected necrotizing pancreatitis evaluated immediate drainage within 24 hours after infected necrosis was diagnosed as compared with postponed drainage. Immediate drainage was not superior to postponed drainage in reducing complications. Patients assigned to immediate drainage underwent a greater number of invasive procedures.


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