Educational objective: Schwannomas present histologically with a biphasic pattern of cellularity (Antoni A and B areas) and S-100 positivity (indicating neural crest origin). Schwannomas can arise from the peripheral nerves, nerve roots, and cranial nerves (except CN II and CN I). Acoustic neuromas are the most common type of intracranial schwannoma and are located at the cerebellopontine angle at CN VIII.
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