Educational objective: Inadequate blood supply to the brain (e | Uworld | Step 1

Educational objective: Inadequate blood supply to the brain (eg, arterial thrombosis or embolism) leads to ischemic stroke. The first microscopic changes are typically seen 12-24 hours after irreversible ischemic injury and include intense eosinophilic staining of the neuronal cytoplasm (red neurons) and nuclear fragmentation.