UPDATES IN MEDICINE

2021-07-28 05:23:55 ​​ Sperm Parameters Before and After COVID-19 mRNA Vaccination

Despite high efficacy and few adverse events found in clinical trials, only 56% of individuals in the US reported wanting to receive the vaccine. One of the reasons for vaccine hesitancy is the potential negative effect on fertility.

In this study of sperm parameters before and after 2 doses of a COVID-19 mRNA vaccine, there were no significant decreases in any sperm parameter among this small cohort of healthy men.


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2021-07-26 19:01:50 ​​ Features of Myopericarditis in Children After mRNA Vaccination for COVID-19

● Myopericarditis occurred in 13 teens (median age, 15 years; 12 male) after the second dose of COVID-19 mRNA vaccine.

● Ten teens were non-Hispanic white, two were Asian, and one was American Indian/Alaska Native.

● Symptoms developed a median of 3 days after second vaccination.

● All received nonsteroidal anti-inflammatory medications. Two patients with LV abnormalities received corticosteroids and intravenous immunoglobulin.

● Median hospital stay was 2 days; no patient required intensive care.

● All patients survived and improved without further morbidity prior to discharge.


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2021-07-23 18:25:45 ​​ Household Transmission of SARS-CoV-2 from Children

In an outbreak of Covid-19 at a summer camp, 224 confirmed cases in children and adolescents 7 to 19 years of age were identified. After the campers returned home, transmission of SARS-CoV-2 occurred in 35 of 194 (18%) households, with a secondary attack rate of 45% among household members.


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2021-07-22 19:35:40 ​​ Vaccine Effectiveness against Delta Covid-19 Variant

The B.1.617.2 (delta) Covid-19 variant has surged in India and spread worldwide. In a test-negative case–control study, the effectiveness of two doses of BNT162b2 (Pfizer) was 94% against the B.1.1.7 (alpha) variant and 88% against delta; with the ChAdOx1 nCoV-19 (Oxford, AstraZeneca) vaccine, effectiveness was 74% and 67%, respectively. Protection after a single vaccine injection was low; two doses are needed.


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2021-07-22 04:26:40 Join The Discussion Group @Medical_Discussion_1 Open / Comment

2021-07-21 11:55:09 ​​ Myocarditis Following Immunization With mRNA COVID-19 Vaccines
(in Members of the US Military)

● Findings - In this case series of 23 male patients, including 22 previously healthy military members, myocarditis was identified within 4 days of receipt of a COVID-19 vaccine. For most patients (n = 20), the diagnosis was made after the second dose of mRNA COVID-19 vaccine; these episodes occurred against the backdrop of 2.8 million doses of mRNA COVID-19 vaccines administered.

● Meaning - Vigilance for rare adverse events, including myocarditis, after COVID-19 vaccination is warranted but should not diminish overall confidence in vaccination during the current pandemic.


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2021-07-20 06:01:54 ​​ Abelacimab for Prevention of Venous Thromboembolism

In patients undergoing total knee replacement, a single injection of abelacimab (an antibody to factor XI) administered postoperatively was superior to standard care with enoxaparin for the prevention of venous thromboembolism. Bleeding events were rare.


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2021-07-18 18:30:20 ​​ Bamlanivimab plus Etesevimab for Covid-19

In a phase 3 trial involving 1035 outpatients who were at increased risk for severe Covid-19, those who received two monoclonal antibodies targeting SARS-CoV-2 had a significant reduction in the viral load and a significantly lower incidence of progression to severe illness than those who received placebo.


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2021-07-17 16:41:25 ​​ Detecting Speech in a Paralyzed Person with Anarthria

In a person with anarthria and spastic quadriparesis caused by a brain-stem stroke, signals from the cortical speech area were processed with signal analysis and a natural-language model. It was possible to decode words and sentences with high accuracy when the patient attempted to produce language.


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2021-07-11 19:57:56 ​​ Hybrid immunity in patient with past COVID-19 infection after vaccination

Determining the quality and duration of that immunity for COVID 19 is vital. But the adaptive immune system is complex, and these factors may differ between natural immunity (obtained by infection) and vaccine-generated immunity. Additionally, there is the question of the combination: What kind of immunity develops in people with natural immunity who are subsequently vaccinated? Such “hybrid immunity” is particularly interesting because of the notable finding that people with previous SARS-CoV-2 infection mount unusually potent immune responses to COVID-19 vaccines 


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