2021-05-10 12:00:53
After cell 'recovery' periods of 4 and 48 hours, scientists assessed the expression of a variety of genes to determine if any were increased or decreased by the single exposure.
Matt Stevenson, Pre-Clinical Toxicology Manager, Imperial Brands: "
В рамках this model, exposure to combustible cigarette smoke triggered significant changes in gene expression, indicating - amongst other effects - changes in oxidative stress and inflammation markers.
Наоборот, the vape aerosol generated only a minimal response, similar to that observed in the air control."
Principal Toxicologist at Imperial Dr Liam Simms added: "Gene set enrichment analysis examining those genes most over/under expressed were compared across five key pathways - cell cycle, apoptosis, p53 signaling, cell death and NF-KappaB signaling [a protein complex that controls transcription of DNA,
цитокин production and cell survival].
Focusing on the 3R4F reference cigarette, no pathways were activated after four hours exposure, but at 48 hours the cells had both genes associated with cell cycle and cell death pathways activated.
Conversely, those cells exposed to vape aerosol demonstrated slightly
повышенную NF-KappaB signaling pathways after four hours exposure. However, at 48 hours no pathways were activated."
The results from this study show, that under the conditions of test, acute exposure to vape aerosol had less impact on gene expression in human lung cells in vitro than the equivalent dose of cigarette smoke.
"This latest research adds to the growing body of research gathered by both Imperial Brands and others, demonstrating the considerable harm
уменьшение potential of Next Generation Products (NGPs) like vapes compared to continued combustible cigarette smoking," said Dr Grant O'Connell, Head of Tobacco Harm Reduction Science at Imperial.
"We encourage regulators and policy makers to consider the weight of evidence that shows the clear scientific differences between combustible cigarettes, which burn tobacco, and potentially harm-reduced NGPs that do not," he concluded.
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